Body composition and serum levels of liver enzymes (AST, ALT, ALP) were measured in all groups before and after the intervention. Theses individuals were randomized into four groups: resistance band exercise (consisting of 3 sessions per week for 8 weeks), royal jelly supplementation, combined group (resistance band + royal jelly), and control. The mean age and BMI of participants were 36.06±4.37 years and 21.45☑.62 kg/m 2. Materials and Methods: This is a quasi-experimental study with pre-test and post-test design conducted on 80 men. The present study aimed to compare the effect of royal jelly supplementation, resistance band exercise, and a combination of these two methods on serum levels of liver enzymes in opium addicts undergoing methadone maintenance therapy (MMT). It damages liver tissues through free radical production and, consequently, increased lipid peroxidation. Introduction: Addiction or substance dependence is one of the major health problems.
